Syllabus is Mentioned Below:-
UNIT - I Preformulation studies: Goals of Preformulation, preformulation parameters, Polymorphs and Amorphous forms, selection of drugs- solubility, partition coefficient, salt forms, humidity, solid state properties, Particle Size Analysis (Laser Diffraction and Dynamic Light Scattering) drug -excipient compatibility, flow properties, format and content of reports of preformulation, preformulation stability studies (ICH).
UNIT - II Formulation development of solid dosage forms &ndash; I: New materials, excipients science - diluents, disintegrants, super disintegrants, etc, evaluation of functional properties of excipients, co-processed materials, methods of preparation and evaluation.
UNIT - III Formulation development of solid dosage forms &ndash; II: Coating, coating machines, coating techniques in tablet technology for product development, computerization, inprocess control of tablets, formulation development and manufacture of powder dosage forms for internal use.
Microencapsulation - Types, methodology, problems encountered.
UNIT - IV Formulation development of soft and hard gelatin capsules: Introduction, production and methods of manufacture, filling equipment and filling operations, formulations, finishing, special techniques, advances in capsule manufacture, machines, processing and control including pharmaceutical aspects, physical stability and packaging.
UNIT - V Optimization techniques in pharmaceutical formulation and processing: Introduction, optimization parameters, statistical design, response surface method, contour diagrams, factorial design, partial factorial design, simplex methods, mixture designs, Placket Burhan method, Box Benken method, applications in pharmaceutical formulation.
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Modern Pharmaceutics 1

CW Pharmacy Official

Syllabus is Mentioned Below:-
UNIT - I Polymer science: Classification, properties and characterization of polymers, phase separation, polymers in solid state, preparation of polymer solution, application of polymers in pharmaceutical formulations. Mechanism of biodegradation of biodegradable polymers including controlled drug delivery systems, Mucoadhesive, Hydrodynamically balanced and Transdermal Systems.
UNIT - II Physics of tablet compression: Basic principles of interactions, compression and consolidation, compression and consolidation under high loads, effect of friction, distribution of forces in compaction, force volume relationships, Heckel plots, compaction profiles, energy involved in compaction, Measurement of compression with strain gauges, compression pressure - QA parameters.
UNIT - III Kinetics and drug stability: Stability calculations, rate equations, complex order kinetics, Factors influencing stability, strategy of stability testing, method of stabilization, method of accelerated stability testing in dosage forms, temperature and humidity control, physical stability testing of pharmaceutical products. Photodecomposition, Method, solid state decomposition.
UNIT - IV Theoretical consideration, instrumentation, rheological properties of disperse systems and semisolids. Oscillatory testing, Creep measurement.
Characterization of API and excipients: Differential Scanning Calorimetry: Principle, thermal transitions, advantages, disadvantages, instrumentation, applications and interpretations.
X Ray Diffraction methods: Origin of x-rays, principle, advantages, disadvantages, instrumentation, applications and interpretations.
UNIT - V Dissolution and solubility: Solubility and solubilization of nonelectrolytes, solubilization by the use of surfactants, cosolvents, complexation, drug derivatization and solid state manipulation, Mechanisms of Drug release - dissolution, diffusion (Matrix and Reservoir) and swelling controlled (Peppas Model) and dissolution equipment.
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Advanced Physical Pharmaceutics

UNIT - I
a. Biological and metabolic factors affecting bioavailability, complexation, dissolution - techniques of enhancing dissolution.
b. Formulation factors affecting bioavailability of drugs in dosage forms of tablets, capsules, Parenteral, liquid orals and topical dosage forms.
c. Bioavailability: Importance, dose dependency, AUC, rate and extent, assessment, blood and urine samples, single dose and multiple dose studies, Invitro- Invivo Correlation analysis and Levels of Correlations.
d. Bioequivalence: Importance equivalency concepts, biowaivers, study designs, protocol, transformation of data, Statistical Criteria as per the Regulations.
UNIT II - Pharmacokinetics &ndash; Drug Disposition: compartment models: One, two and non-compartmental approaches to pharmacokinetics. Recent trends, merits and limitations of these approaches.
Application of these models to determine the various pharmacokinetic parameters pertaining to:
a. Distribution: Apparent volume of distribution and its determination, factors affecting.
b. Metabolism: Metabolic rate constant, Factors affecting Metabolism.
c. Elimination: Over all apparent elimination rate constant, and half life. All the above under the following conditions:
1. Intravenous infusion
2. Multiple dose injections.
d. Non-invasive methods of estimating pharmacokinetics parameters with emphasis on salivary and urinary samples.
e. Concept of clearance: organ, total clearance, hepatic clearance, lung clearance and renal clearance.
UNIT - IIIPharmacokinetics &ndash; Absorption: Rate constants &ndash; Zero order, first order, Models of experimental study of absorption (in silico, in vitro, in situ and in vivo) &ndash; Absorption half lives, method of residuals, Wagner &ndash; Nelson method, Loo - Reigleman method, Analysis of kinetics from urine samples. Pharmacokinetic parameters determination pertaining to: Multiple dosage oral administration.
UNIT - IV Non-linear pharmacokinetics: Concepts of linear and non-linear pharmacokinetics, Michaelis- Menton kinetics characteristics. Basic kinetic parameters, possible causes of non-induction, nonlinear binding, and non-linearity of pharmacological responses.
Clinical Pharmacokinetics: Altered kinetics in pregnancy, child birth, infants and geriatrics.
UNIT - V Time dependent pharmacokinetics: Introduction, classification, physiologically induced time dependency: Chronopharmacokinetics - principles, drugs&ndash; (amino glycosides, NSAIDS, antihypertensive drug) chemically induced dependency.
Drug Interactions: Kinetics of drug interaction, study of drug-drug interaction mediated through absorption, distribution, metabolism and elimination, mechanisms of interaction and consequence. Numerical problems associated with all units, if any.
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Advanced Biopharmaceutics & Pharmacokinetics

Syllabus is Mentioned Below:-
Unit 1 - Fundamentals of controlled drug delivery systems, pharmacokinetic and pharmacodynamics basis of controlled drug delivery. Design, fabrication, evaluation and applications of the following controlled releasing systems.
a. Controlled release oral drug delivery systems.
b. Parenteral controlled release drug delivery systems.
Unit 2 - Design, fabrication, evaluation and applications of the following:-
a. Implantable Therapeutic systems
b. Transdermal delivery systems
c. Ocular and Intrauterine delivery systems
d. Vaccine delivery: Delivery systems used to promote uptake, absorption enhancers, oral immunization; controlled release micro particles form vaccine development.
Unit 3 - Biochemical and molecular biology approaches to controlled drug delivery of:-
a. Bioadhesive drug delivery systems
b. Nasal drug delivery systems
c. Drug delivery to Colon.
Unit 4 - Biochemical and molecular biology approaches to control drug delivery of:-
a. Liposomes
b. Niosomes
c. Microspheres
d. Nanoparticles
e. Resealed erythrocytes
Unit V - Drug targeting to particular organs:-
a. Delivery to lungs
b. Delivery to the brain and problems involved
c. Drug targeting in neoplasams.
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Advanced Drug Delivery System

Syllabus is Mentioned Below:-
Unit - I Pilot plant scale-up techniques used in pharmaceutical manufacturing.
a. Pilot plant: Technology transfer from R&amp;D to pilot plant to pilot scale considerations of steps involved with manufacture, layout design, facility, equipment selection of tablets, capsules, suspensions, emulsions &amp; semisolids.
b. Scale up: Importance, Scale up process-size reduction, mixing, blending, granulation, compression, coating involved in tablets, capsules &amp; liquid-liquid mixing.
Unit II - Formulation development of Parenteral dosage forms: Advances in materials and production techniques, filling machines, sterilizers, product layout.
Unit III - Pharmaceutical Aerosols: Advances in propellants, metered dose inhaler designs, dry powder inhalers, selection of containers and formulation aspects in aerosols formulation, manufacture and quality control.
Unit - IV
a. Cosmetics: Formulation approaches, preparation &amp; method of manufacturing labelling &amp; Q.C. of anti-ageing products, sun screen lotion and fairness creams.
b. Nutraceuticals:
1. Introduction, source, manufacture and analysis of glucosamine &amp; cartinine.
2. Monographs: General and specific properties of glucosamine &amp; cartinine.
3. A brief overview of role of Nutraceuticals in cancer prevention &amp; cardio vascular disorders.
Unit V - Aseptic processing operation
a. Introduction, contamination control, microbial environmental monitoring, microbiological testing of water, microbiological air testing, characterization of aseptic process, media and incubation condition, theoretical evaluation of aseptic operations.
b. Air handling systems: Study of AHUs, humidity &amp; temperature control.
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Modern Pharmaceutics 2

Syllabus is Mentioned Below:-
Unit - I Pharmaceutical unit operations: A detailed study involving machinery and theory of Pharmaceutical unit operations like milling, mixing, filtration, and drying.
Unit - II
a. Materials of construction of pharmaceutical equipment and packaging materials: Study of the principles, production techniques in the large scale production of tablets, capsules, suspensions, liquid pharmaceuticals, ophthalmic products and sterile products.
b. Qualification of equipment (IQ, OQ, PQ).
Unit - III Production management: Production organization, objectives and policies of good manufacturing practices, layout of buildings, services, equipments and their maintenance, material management, handling and transportation, inventory management and control, production and planning control, Sales forecasting, budget and cost control, industrial and personal relationship. Total Quality Management (TQM).
Unit IV - Effluent Testing and Treatment: Effluent analysis, specifications and preventive measures water of pollution, solid pollution, air pollution and sound pollution.
Unit - V Validation: Regulatory basis, validation of analytical methods, and process, in solid dosage forms, sterile products, and liquid dosage forms.
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Industrial Pharmacy

Syllabus is Mentioned Below:-
Unit - 1 Introduction to Nanotechnology
a. Definition of nanotechnology
b. History of nanotechnology
c. Unique properties and classification of Nanomaterials
d. Role of size and size distribution of nanoparticles properties.
e. Marketed formulations based on nanotechnology and science behind them
Unit - 2 Synthesis of Nanomaterials
Physical, chemical and biological Methods
Methods for synthesis of:- Gold nanoparticles
Magnetic nanoparticles
Polymeric nanoparticles
Self &ndash; assembly structures such as liposomes, Niosomes, transferasomes, micelles, aquasomes and Nanoemulsions.
Unit - 3 Biomedical applications of Nanotechnology
a. Nanotechnology products used for in vitro diagnostics
b. Improvements to medical or molecular imaging using nanotechnology
c. Targeted nanomaterials for diagnostic and therapeutic purpose
Unit - 4 Design of nanomaterials for drug delivery, pulmonary and nasal drug delivery, nanomaterials for cancer therapy and cardiovascular diseases. Localized drug delivery systems.
Unit - 5 Characterization including the principles, size reduction, analysis of nanoparticles, size, PDI, size separation, stability, methods of analysis regarding integrity and release of drugs.
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Nano Drug Delivery System

Syllabus is Mentioned Below:-
Unit I - Principles and procedures involved in the determination of the official compounds in IP with the following analytical techniques:
A. Non-aqueous
B. Oxidation-reduction
C. Complexometric
D. Diazotization methods
E. Neutralization
F. Acid &ndash; Base
Unit II - A detailed study of the principles and procedures involved in the quantitative determination of the following organic functional groups:
A. Amines
B. Esters
C. Carbonyl compounds
D. Hydroxy and carboxyl
E. Amino Acids
Unit III
a. Reference Standards: Types, preparation methods and uses.
b. Principles and procedures involved in using the following reagents in the determination of pharmaceutical dosage forms official in IP
a. MBTH (3-methyl-2-benzothiazolone hydrazone)
b. F.C. Reagent (Folin-Ciocalteu)
c. PDAB (para-Dimethyl Amino Benzaldehyde)
d. 2, 3, 5 - triPhenyltetrazolium salt
e. 2, 6 di -Chloroquinone Chlorimide
f. N - (1-naphthyl) ethylenediaminedihydrochloride (B.M. Reagent)
g. Carr &ndash; Price Reagent
h. 2,4 - DNP
Unit IV
a. Analysis of Excipients: Tests related to excipients such as bulk density, tapped density, particle size distribution, pH, moisture content, viscosity (dynamic), loss on drying, ash content, and conductivity.
b. Excipients of interest: Disintegrating agents, binders, emulsifiers, viscosity modifiers and preservatives including preservative challenge test.
Unit V
a. Dissolution Tests: Types of Dissolution apparatus, dissolution test requirements for immediate release, delayed release, extended release dosage forms, coated, uncoated, enteric coated, gelatin capsules etc.
b. Microbiological assays and Biological tests: Antimicrobial effectiveness testing, microbial limit tests, sterility test. Antibiotics-microbial assays, bacterial endotoxins test.
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Advanced Pharmaceutical Analysis

Syllabus is Mentioned Below:-
Unit 1
a. Carbohydrates: classification and properties of food carbohydrates, General methods of analysis of food carbohydrates. 
b. Proteins: Chemistry and classification of amino acids and proteins, Physico-Chemical properties of protein and their structure, general methods of analysis of proteins and amino acids.
Unit 2 Probiotic: Definition, History of Probiotics, Probiotics Identification, Mechanisms, Advantages of Probiotics, Disadvantages, Applications of probiotics.
Unit 3 Lipids: Classification, general methods of analysis, refining of fats and oils; hydrogenation of vegetable oils, Determination of adulteration in fats and oils.
Unit 4 Vitamins: classification of vitamins, methods of analysis of vitamins, Principles of microbial assay of vitamins of B-series.
Unit 5
a. General Analytical methods for milk, milk constituents and milk products like ice cream, milk powder, butter, margarine, cheese including adulterants and contaminants of milk.
b. Analysis of fermentation products like wine, spirits, beer and vinegar.
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Pharmaceutical Food Analysis

Syllabus is Mentioned Below:-
Unit - 1
a. Impurity and stability studies: Definition, classification of impurities in drug Substance or Active Pharmaceutical Ingredients and quantification of impurities as per ICH guidelines.
b. Impurities in new drug products: Rationale for the reporting and control of degradation products, reporting degradation products content of batches, listing of degradation products in specifications, qualification of degradation products.
c. Impurities in residual solvents: General principles, classification of residual solvents, Analytical procedures, limits of residual solvents, reporting levels of residual solvents.
Unit - 2
a. Concepts of Quality Assurance, Total Quality Management, Philosophy of GMP and cGMP
b. Guidelines for Quality Assurance of Human Blood Products and large volume parenterals.
Unit - 3
a. Organization and personnel, responsibilities, training hygiene
b. Premises: Location, design, plan Layout, construction, maintenance and sanitations, environmental control, sterile areas, control of contamination.
c. Equipments: Selection, purchase specifications, maintenance, clean in place, sterilize in place.Raw &ndash; materials: Purchase specifications, maintenance of stores, selection of vendors, controls and raw materials.
Unit - 4
a. Packaging and labeling controls, line clearance and other packaging materials.
b. Quality Control Laboratory: Responsibilities, good laboratory practices, routine controls, instruments, protocols, non-clinical testing, controls on animal house, data generation and storage.
Unit - 5 Manufacture and controls on dosage forms
a. Manufacturing documents, Master Formula, Batch Formula, Records, Standard Operating Procedures
b. In process quality control on various dosage forms sterile and biological products, standard operating procedures for various operations like cleaning, filling, drying, compression, coating, disinfection, sterilization, membrane filtration etc.
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